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Abstract Osteoarthritis is a common degenerative joint disease characterized by progressive cartilage loss, bone remodeling, and chronic joint inflammation, yet its underlying mechanisms remain incompletely understood

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Ileus is noted as potentially life-threatening, and the FDA Adverse Event Reporting System (FAERS) has recorded 33 cases, including two fatalities, linked to GLP-1 agonists

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Clinical trials demonstrated average weight loss of approximately 15% of body weight